Title: Designing Biological Systems for Health and Livability
Our overarching goal is the rapid and predictable reprogramming of cells of all types. We seek to implement design strategies used by Nature as well as to go where evolution may not readily go. The implications of our work range from developing systems to study biological processes, novel therapeutics and the environment...
Title: Powering Computation in Living Cells with Synthetic Biology
The Synthetic Biology Group is focused on advancing fundamental designs and applications for synthetic biology. Using principles inspired by electrical engineering and computer science, we are developing new techniques for constructing, probing, modulating, and modeling engineered biological circuits. Our current application areas include infectious diseases, amyloid-associated conditions, and nanotechnology.
Title: Encoded genomic logic for embryonic development
The major focus of research in our laboratory is the systems biology of the gene regulatory networks that control development, and the evolution of these networks. Our research is done on sea urchin embryos, which provide key experimental advantages. Among these are: an easy gene transfer technology, with high throughput technologies available
Title: The biological microprocessor, or how to build a computer with biological parts
The Leukippos Institute is building a synthetic biology lab in the cloud. We are exploring novel, open, web based forms of collaboration. The focus of our work is on in silico projects. CytoComp, a young startup, is focused on biological computing. By applying synthetic biology and nanobioelectronics, we engineer solutions to monitor and control biological systems.
The Isaacs Laboratory is focused on developing foundational cellular and biomolecular engineering technologies to understand and engineer biological systems. Our approach is designed to integrate engineering and evolution through the construction of genes, gene networks and whole genomes alongside quantitative models to gain a better understanding of whole biological systems. In turn, we utilize these insights to design and evolve living cells with new, improved and desired function. We seek to uncover new properties of biological systems and generate new phenotypes with the ultimate goal of applying these insights to address global challenges in medicine, energy supply and the environment.
Title: Programming Nucleic Acids Self-Assembly
My research interests lie at the interface of information science, molecular engineering, and biology. The current focus is to engineer information directed self-assembly of nucleic acid (DNA/RNA) structures and devices, and to exploit such systems to do useful molecular work, e.g. probing and programming biological processes for imaging and therapeutic applications.
Introducing Electronic Nanointerfaces into Organisms using Synthetic Biology.
Her research explores and engineers the interface between living organisms and non-living materials at the nanoscale. By programming processes such as electron transfer and biomineralization, she is working to enable cells to communicate electronically with electrodes and to control the synthesis of inorganic materials. She is working toward creating a new class of smart, self-renewing materials based on genetically reconfigured living cells seamlessly integrated with human-made components.
Title: Accelerating information access: challenges in genomics and the 21st century
Based on the continuous curation of the currently best characterized regulatory network of a living cell, that of E.coli K-12 (found both in RegulonDB and in EcoCyc databases), research in the lab is centered in the computational design, genomic prediction, and comparative and evolutionary analyses of regulation of gene expression in bacteria…
Title: Nanobiotechnology and Synthetic Biology to Design Novel Therapeutics Against Infectious Diseases
Our laboratory, The Nano-Biotechnology Research Group does research inspired in the fields of Nanotechnology and Systems and Synthetic Biology to advance in the development and design of therapeutics, materials, alternative and clean energy, and contribute to increase the world’s food and water supplies.
Title: Engineering synthetic sensing and signal transduction traits in plants
His Lab is interested in developing artificially-controlled genetic networks to program plants and plant cells to perform desired functions. Synthetic genetic switches can be introduced into plants to precisely control gene expression, rewiring natural signaling and metabolic pathways, or generating novel traits. Engineering these systems to behave according to specific inputs can serve both basic research and field-applied purposes, allowing applications that range from enhancing crop productivity to on-demand bio-manufacturing…
Title: Circuit Design in Synthetic Biology
We are developing a basis by which cells can be programmed like robots to perform complex, coordinated tasks for pharmaceutical and industrial applications. We are engineering new sensors that give bacteria the senses of touch, sight, and smell. Genetic circuits — analogous to their electronic counterparts — are built to integrate the signals from the various sensors. Finally, the output of the gene circuits is used to control cellular processes.
Title: Bistability and trigger waves in the regulation of mitosis
We have been studying the system of regulatory proteins that drives the cell cycle, through a combination of quantitative experimental approaches, computational modeling, and the theory of nonlinear dynamics. Our goal is to understand the design principles of this system, and perhaps to gain insight into the systems that drive other biological oscillations (e.g. heart beats, calcium oscillations, circadian rhythms) as well.
Title: Strain Development Pipeline for the Successful Manufacturing of Renewable Products
Amyris is a renewable products company providing sustainable alternatives to a broad range of petroleum-sourced products. Amyris applies its industrial synthetic biology platform to convert plant sugars into a variety of molecules -- flexible building blocks that can be used in a wide range of products.